The IRCV team is working on mechanisms involved in the tumor escape from the immune system and on proposal for immunotherapy strategies in cancers.
Immunoregulation of Virus-associated Cancers
Our main area of investigation includes immunological events occurring in tumor pathologies associated with viral infections. We are particularly interested in hepatitis C virus (HCV) and Epstein – Barr virus (EBV) infections, which are described in major cases of human hepatocellular carcinoma and epithelial malignancies, respectively. In the context of these viral infections, our team studies both effector and regulatory T lymphocyte (Treg) immune responses during tumoral processes.
In addition, we are contributing to the development of immunotherapies, (i) using peptide presentation to effector targets, in order to prime anti-tumor immunity in EBV-associated malignancies and (ii) using small oncolytic viruses which specifically target and lyse tumor cells in hepatocellular carcinoma linked, but not exclusively, to HCV infection.