• Alessandro Furlan and David Tulasne. How does Met regulate the survival/apoptosis balance? Hepatology (2013) in press. Letter to the editor.
  • Ladam F, Damour I, Dumont P, Kherrouche Z, de Launoit Y, Tulasne D and Chotteau-Lelievre A. Loss of negative regulatory feedback loop involving Pea3 and Cyclin D2 is required for Pea3 induced migration in transformed mammary epithelial cells. Mol Cancer Res. (2013) 11:1412-24.
  • Lefebvre J, Muharram G, Leroy C, Kherrouche Z, Montagne R, Ichin G, Tauszig-Delamasure S, Chotteau-Lelievre, Brenner C, Mehlen P and Tulasne D. Caspase-generated fragment of the Met receptor favors apoptosis via the intrinsic pathway independently of its tyrosine kinase activity. Cell death and Disease. Oct 17;4:e871.
  • Ichim G, Genevois AL, Ménard M, Yu LY, Coelho-Aguiar JM, Llambi F, Jarrosson-Wuilleme L, Lefebvre J, Tulasne D, Dupin E, Le Douarin N, Arumäe U, Tauszig-Delamasure S, Mehlen P. The Dependence Receptor TrkC Triggers Mitochondria-Dependent Apoptosis upon Cobra-1 Recruitment. Mol Cell. (2013) 51:632-46.



  • Ancot F, Leroy C, Muharram G, Lefebvre J, Vicogne J, Lemiere A, Kherrouche Z, Foveau B, Pourtier A, Melnyk O, Giordano S, Chotteau-Lelievre A, Tulasne D. Shedding-Generated Met Receptor Fragments can be Routed to Either the Proteasomal or the Lysosomal Degradation Pathway. Traffic (2012) 13:1261-72.
  • Lefebvre J, Ancot F, Leroy C, Muharram G, Lemière A, and Tulasne D. Met degradation: more than one stone to shoot a receptor down. FASEB J (2012) 4:1387-99. Review.
  • Bobowski M, Cazet A, Yoann Rombouts Y, Lefebvre J, Steenacker A, Popa I, Guérardel Y,  Le Bourhis X, Tulasne D and Delannoy P. The ganglioside GD2 induces the constitutive activation of c-Met in MDA-MB-231 breast cancer cells expressing the GD3 synthase. Glycobiology (2012) 22:806-16.
  • Richard A, and Tulasne D. Caspase cleavage of viral proteins, another way for viruses to make the best of apoptosis. Cell Death and Disease (2012) March; 3(3): e277. Review.
  • Steenackers A, Cazet A, Bobowski M, Rombouts Y, Lefebvre J, Guérardel Y, Tulasne D, Le Bourhis X, Delannoy P. Expression of GD3 synthase modifies ganglioside profile and increases migration of MCF-7 breast cancer cells. Comptes rendus Chimie (2012) 15: 3-14.



  • Marcon L, Kherrouche Z, Lyskawa J, Fournier D, Tulasne D, Woisel P, Boukherroub R. Preparation and characterization of Zonyl-coated nanodiamonds with antifouling properties. Chem Commun (Camb). (2011) 47:5178-80



  • Cazet A, Lefebvre J, Adriaenssens E, Julien S, Bobowski M, Grigoriadis A, Tutt A, Tulasne D, Le Bourhis X, Delannoy P. GD3 synthase expression enhances proliferation and tumor growth of MDA-MB-231 breast cancer cells through c-Met activation. Mol Cancer Res. (2010) 8:1526-35.
  • Choul-Li S, Leroy C, Leprivier G, Laitem C, Tulasne D*, Aumercier M*. (*Equal contribution) Caspase cleavage of Ets-1 p51 generates fragments with transcriptional dominant-negative function. Biochem J. (2010) 426:229-41.



  • Deheuninck J., Goormachtigh G., Foveau B., Ji Z., Leroy C., Ancot F., Villeret V., Tulasne D. and Fafeur V. Phosphorylation of the MET receptor on juxtamembrane tyrosine residue 1001 inhibits its caspase-dependent cleavage. Cell Signal. (2009) 21:1455-63.
  • Foveau B., Ancot F., Leroy C., Petrelli A., Reiss K., Vingtdeux V., Giordano S., Fafeur V. and Tulasne D. Downregulation of the Met Receptor Tyrosine Kinase by Presenilin-dependent Regulated Intramembrane Proteolysis. Mol Biol Cell. (2009) 20:2494-2506.
  • Ancot F, Foveau B, Lefebvre J, Leroy C and Tulasne D. Proteolytic cleavages give receptor tyrosine kinases the gift of ubiquity. Oncogene. (2009) 28:2185-95. Review.


2008 -2004

  • Tulasne D and Foveau B. The shadow of death on the MET tyrosine kinase receptor. Cell Death Differ. (2008)15:427-34. Review.
  • Deheuninck J, Foveau B, Goormachtigh G, Leroy C, Ji Z, Tulasne D. and Fafeur V. Caspase cleavage of the MET receptor generates an HGF interfering fragment. Biochem Biophys Res Commun. (2008) 367:573-7
  • Yan Y, Tulasne D, Browaeys E, Cailliau K, Khayath N, Pierce RJ, Trolet J, Fafeur V, Ben Younes A, Dissous C. Molecular cloning and characterisation of SmSLK, a novel Ste20-like kinase in Schistosoma mansoni. Int J Parasitol. (2007) 14:1539-50.
  • Foveau B., Leroy C., Ancot F., Deheuninck J., Ji Z., Fafeur V. and Tulasne D. Amplification of apoptosis through sequential caspase cleavage of the MET tyrosine kinase receptor. Cell Death Differ. (2007) 14:752-64.
  • Ji Z., Degerny C., Vintonenko N., Deheuninck J., Foveau B., Leroy C., Coll J., Tulasne D., Baert JL and Fafeur V. Regulation of the Ets-1 transcription factor by sumoylation and ubiquitinylation. Oncogene. (2007) 26:395-406.
  • Leroy C, Deheuninck J, Reveneau S, Foveau B, Ji Z, Villenet C, Quief S, Tulasne D, Kerckaert JP, Fafeur V. HGF/SF regulates expression of apoptotic genes in MCF-10A human mammary epithelial cells. Ann N Y Acad Sci. (2006) 1090:188-202.
  • Tulasne D., Deheuninck J., Calheiros Lourenco F., Fabienne Lamballe F., Ji Z., Leroy C., Puchois E., Moumen A., Maina F., Mehlen P. and Fafeur V. Pro-apoptotic function of the MET tyrosine kinase receptor through caspase cleavage. Mol Cell Biol. (2004) 24:10328-39.