Cancer Biology and Chemistry team (CBC) was created in 2010 by the association of a chemistry and biology team as a result of a fruitful collaboration since 2006. The research activity of the chemistry team was focused at that time on the chemistry of peptide and protein bioconjugates for diagnostic and medical applications, whereas whose of the biology team was mainly focussed on the study of hepatocyte growth factor (HGF)/MET tyrosine kinase receptor signalling and its role in tumorigenesis and metastasis. The association of our teams was seen as an opportunity to built new multidisciplinary projects, synergize and develop integrated chemical and biological approaches to understanding and modulate growth factors biological activities.
Today, one important asset is our capacity to innovate in the field of protein total synthesis by developping novel native peptide ligation methods around SEA chemistry and strategies for the chemical assembly of proteins.
The main project of CBC team is focused now on chemical biology approaches aiming at deciphering MET activation mechanisms triggered by HGF at the normal, cancer and stem cell levels using protein total synthesis as a source of novel protein scaffolds.
The team has been awarded the 2013 INPI trophy for the significant valorization of its research. See the INPI web site