The team is studying the tumor suppressor gene HIC1 (Hypermethylated in Cancer 1) encoding a transcriptional repressor which is epigenetically silenced but not mutated in tumors. HIC1 has broad biological roles during normal development and is implicated in many canonical processes of cancer such as control of cell growth and cell survival upon genotoxic stress, notably through regulatory loops with P53 and E2F1. Our recent work has implicated HIC1 as a new key player in the DNA-damage response.