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Publications

2015

 The Unfolded Protein Response and Cellular Senescence.
 Pluquet O, Pourtier A, Abbadie C.
 Am J Physiol – Cell Physiol. 2015 In Press
 Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

2014

 Level of macroautophagy drives senescent keratinocytes into cell death or neoplastic evasion.
 Deruy E, Nassour J, Martin N, Vercamer C, Malaquin N, Bertout J, Chelli F, Pourtier A, Pluquet O, Abbadie C.
 Cell Death Dis. 2014; 5:e1577
 Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

Ets-1 controls breast cancer cell balance between invasion and growth.
Furlan A, Vercamer C, Bouali F, Damour I, Chotteau-Lelievre A, Wernert N, Desbiens X, Pourtier A.
Int J Cancer. 2014; 135:2317-28
Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

Identification of a gene signature of a pre-transformation process by senescence evasion in normal human epidermal keratinocytes.
Martin N, Salazar-Cardozo C, Vercamer C, Ott L, Marot G, Slijepcevic P, Abbadie C, Pluquet O. 
Mol Cancer. 2014; 13:151.

Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

Watching the clock: endoplasmic reticulum-mediated control of circadian rhythms in cancer.
Pluquet O, Dejeans N, Chevet E. 
Annals of Medicine. 2014; 46(4): 233-43.

Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

2013

DNA double-strand breaks lead to activation of hypermethylated in cancer 1 (HIC1) by SUMOylation to regulate DNA repair.
Dehennaut V, Loison I, Dubuissez M, Nassour J, Abbadie C, Leprince D. 
J Biol Chem. 2013; 288(15): 10254-10264.

Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

Senescent fibroblasts enhance early skin carcinogenic events via a paracrine MMP-PAR-1 axis.
Malaquin N, Vercamer C, Bouali F, Martien S, Deruy E, Wernert N, Chwastyniak M, Pinet F, Abbadie C, Pourtier A. 
PLoS One. 2013; 8(5): e63607.

Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

Cellular senescence involves an intracrine prostaglandin E2 pathway in human fibroblasts.
Martien S, Pluquet O, Vercamer C, Malaquin N, Martin N, Gosselin K, Pourtier A, Abbadie C. 
Biochim Biophys Acta. 2013; 1831(7): 1217-1227.

Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

Posttranscriptional regulation of PER1 underlies the oncogenic function of IREα.
Pluquet O, Dejeans N, Bouchecareilh M, Lhomond S, Pineau R, Higa A, Delugin M, Combe C, Loriot S, Cubel G, Dugot-Senant N, Vital A, Loiseau H, Gosline SJ, Taouji S, Saltel F, Hallett M, Sarkaria JN, Anderson K, Wu W, Rodriguez FJ, Rosenbaum J, Fernandez-Zapico ME, Chevet E. 
Cancer Res. 2013; 73(15): 4732-4743.

Abstract

˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜˜

2012

Boulay G, Malaquin N, Loison I, Foveau B, Van Rechem C, Rood BR, Pourtier A, Leprince D. Loss of hypermethylated In Cancer 1 (HIC1) in breast cancer cells contributes to stress induced migration and invasion through β-2 adrenergic receptor (ADRB2) misregulation. J Biol Chem. 2012; 287: 5379-5389.

 

Lehen’kyi V, Khalimonchyk S, Pourtier A, Raphaël M, Prevarskaya N. Tumor Xenograft Models to Study the Role of TRP Channels in Tumorigenesis. Springer Protocols. Book Title: TRP Channels in Drug Discovery : Volume II. Series: Methods in Pharmacology and Toxicology. 2012, Vol 1: 391-399.

 

Ancot F, Leroy C, Muharram G, Lefebvre J, Vicogne J, Lemiere A, Kherrouche Z, Foveau B, Pourtier A, Melnyk O, Giordano S, Chotteau-Lelievre A, Tulasne D. Shedding-generated Met receptor fragments can be routed to either the proteasomal or the lysosomal degradation pathway. Traffic. 2012; 13(9): 1261-1272.

 

Dejeans N, Pluquet O, Lhomond S, Grise F, Bouchecareilh M, Juin A, Meynard-Cadars M, Bidaud-Meynard A, Gentil C, Moreau V, Saltel F, Chevet E. Autocrine control of glioma cells adhesion and migration through IRE1α-mediated cleavage of SPARC mRNA. J Cell Sci. 2012; 125(Pt 18): 4278-4287.

 

2011

Hahne JC, Fuchs T, Florin A, Edwards D, Pourtier A, Soncin F, Wernert N. Evaluation of effects caused by differentially spliced Ets-1 transcripts in fibroblasts. Int J Oncol. 2011; 39: 1073-82

 

2010

Deruy E, Gosselin K, Vercamer C, Martien S, Bouali F, Slomianny C, Bertout J, Bernard D, Pourtier A, Abbadie C. MnSOD upregulation induces autophagic programmed cell death in senescent keratinocytes. PloS One. 2010; 5(9): e12712.

 

Humbert N, Navaratnam N, Augert A, Da Costa M, Martien S, Wang J, Martinez D, Abbadie C, Carling D, de Launoit Y, Gil J, Bernard D. Regulation of ploidy and senescence by the AMPK-related kinase NUAK1. EMBO J. 2010; 29(2): 376-386.

 

Monet M, Lehen’kyi V, Gackiere F, Firlej V, Vandenberghe M, Roudbaraki M, Gkika D, Pourtier A, Bidaux G, Slomianny C, Delcourt P, Rassendren F, Bergerat JP, Ceraline J, Cabon F, Humez S, Prevarskaya N. Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance. Cancer Res. 2010; 70(3): 1225-1235.

 

Bouchecareilh M, Caruso ME, Roby P, Parent S, Rouleau N, Taouji S, Pluquet O, Bossé R, Moenner M, Chevet E. AlphaScreen-based characterization of the bifunctional kinase/RNase IRE1alpha: a novel and atypical drug target. J Biomol Screen. 2010; 15(4): 406-417.

 

2009

Gosselin K, Deruy E, Martien S, Vercamer C, Bouali F, Dujardin T, Slomianny C, Houel-Renault L, Chelli F, De Launoit Y, Abbadie C. Senescent keratinocytes die by autophagic programmed cell death. Am J Pathol. 2009; 174(2): 423-435.

 

Gosselin K, Martien S, Pourtier A, Vercamer C, Ostoich P, Morat L, Sabatier L, Duprez L, T’kint de Roodenbeke C, Gilson E, Malaquin N, Wernert N, Slijepcevic P, Ashtari M, Chelli F, Deruy E, Vandenbunder B, De Launoit Y, Abbadie C. Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells. Cancer Res. 2009; 69(20): 7917-7925.

 

Humbert N, Martien S, Augert A, Da Costa M, Mauen S, Abbadie C, de Launoit Y, Gil J, Bernard D. A genetic screen identifies topoisomerase 1 as a regulator of senescence. Cancer Res. 2009; 69(10) : 4101-4016.

 

Mokhtari D, Barbu A, Mehmeti I, Vercamer C, Welsh N.Overexpression of the Nuclear Factor-{kappa}B subunit c-Rel protects against human islet cell death in vitro. Am J Physiol Endocrinol Metab. 2009; 297: e1067.

 

Monet M, Gkika D, Lehen’kyi V, Pourtier A, Vanden Abeele F, Bidaux G, Juvin V, Rassendren F, Humez S, Prevarsakaya N. Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta. 2009; 1793(3): 528-539.

 

Sahin A, Vercamer C, Kaminski A, Fuchs T, Florin A, Hahne JC, Mattot V, Pourtier-Manzanedo A, Pietsch T, Fafeur V, Wernert N. Dominant-negative inhibition of Ets 1 suppresses tumor growth, invasion and migration in rat C6 glioma cells and reveals differentially expressed Ets 1 target genes. Int J Oncol. 2009; 34(2): 377-389.

 

Cameron PH, Chevet E, Pluquet O, Thomas DY, Bergeron JJ. Calnexin phosphorylation attenuates the release of partially misfolded alpha1-antitrypsin to the secretory pathway. J Biol Chem. 2009; 284(50): 34570-34579.

 

2008

Furlan A, Vercamer C, Desbiens X, Pourtier A. Ets-1 triggers and orchestrates the malignant phenotype of mammary cancer cells within their matrix environment. J Cell Physiol. 2008; 215(3): 782-793.

 

Molendi-Coste O, Mairesse J, Aubert N, Ghzili H, Abbadie C, Vaudry H, Gonzales B, Anouar Y, Vieau D, Breton C, Laborie C. Maternal perinatal undernutrition impairs chromaffin cells proliferation in the postnatal rat. Horm Metab Res. 2008; 40: 386-390.